Many scientists have found that there is a type of a chronic form of leukemia that can progress into a deadlier stage of the disease. “The findings may provide physicians with an indicator of when this type of cancer – chronic myeloid leukemia (CML) – is progressing, enabling them to make more accurate prognoses for the disease and improved treatment choices. ” says University of California – San Diego.
In CML the ABL enzyme goes in overdrive because of a mixup in the chromosomes that happens during blood cell development. The genes ABL and BCR fuse andcreate a hybrid BCR-ABL enzyme that drives the excessive proliferation of white blood cells. CML progresses from a chronic stage in some hematopoietic stem cells that carry BCR-ABL to the blast crisis stage. This stage is characterized by the over-production of beta-catenin in white blood cells called granulocyte macrophage progenitors (GMP) – in effect, leukemia stem cells. So basically like some chromosomes get all messed up and fuse together and create a deadly hybrid.
read more here
No Comments so far ↓
There are no comments yet...Kick things off by filling out the form below.